Forget about your fellow passengers on the plane. Who cares if you have to be on the plane with them for 5~6 hours, you're the only one who's important, especially on a flight that leaves at 10 PM.
First, you'll need as many items as possible. I'm thinking a suitcase, backpack and a massive yet very ugly pillow.
First up, do not acknowledge the person sitting next to you. If you want to look out the window, assuming you didn't get the window seat, lean over the person. Sure, you never met them before, but who cares.
Once you are allowed to use electronic devices, take out your Macbook (because we all know if you're reading this as a real guide, you have a Mac) and be sure to have the brightness on your display all the way up. The person trying to sleep next to you won't mind one bit.
(At this point, I take out my netbook and watch a few shows because there's no way I'm going to be able to sleep with that dick next to me. He fucking leaned over me 5 times in the first 30 minutes of flight!)
After landing, be sure to take forever to gather your belongings and leave the plane. The person next to you is in no rush to stand up and stretch after sitting for around 6 hours.
Also, make sure to fly AA.